Efectos secundarios del tratamiento para la leucemia linfoblástica aguda .. ( PEG-L asparaginasa; Oncaspar®) administrada por inyección. O Vincristina. L-asparaginase, definition: alkylating anticancer drug used in the treatment of L -asparaginasa, definition: fármaco alquilante antineoplásico, utilizado para el Los efectos secundarios más comunes son nauseas, vómitos. y otros efectos adversos de este grupo de fármacos, ya que estos pacientes los efectos citotóxicos de la quimioterapia son mediados por diversos . Actinomicina D, metotrexato, andrógenos, L-asparaginasa, procarbazina, vincristina.

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IMP with orphan designation in the indication. Plans for treatment or care after the subject has ended the participation in the trial if it is different from the expected normal treatment of that condition. Relapsed or Refractory Acute Lymphoblastic Leukemia.

l-asparaginasa efectos adversos pdf

Cancer AND drug name. Known allergy to any of the drugs used in the study. Known allergy to Captisol a cyclodextrin derivative adverso to solubilize carfilzomib; for a complete listing of Captisol-enabled drugs, see the Ligand Pharmaceuticals, Inc.

The trial involves single site in the Member State concerned.

For agents that have known adverse events occurring beyond 7 days after administration, this period must be extended beyond the time during which adverse events are known to occur. Combination product that includes a device, but does not involve an Advanced Therapy. A group of cancers that usually begins in the bone marrow and results in high numbers of abnormal white blood cells. Phase 1b – To assess the safety and tolerability of carfilzomib, alone and aversos combination with induction chemotherapy, for the treatment of children with relapsed or refractory acute lymphoblastic leukemia ALL -To determine the maximum tolerated dose MTD of carfilzomib in combination with induction chemotherapy.


Son aptos los sujetos que hayan sufrido una alergia previa a la asparaginasa PEG pero que puedan recibir Erwinia. Age 18 years or younger at the time of study treatment initiation. Time to toxicity will be efcetos to differentiate single-agent carfilzomib from carfilzomib in combination with induction chemotherapy? The duration of this interval must be approved by the Onyx study medical monitor. Title of the trial for lay people, in easily understood, i. The IMP has been designated in this indication as an orphan drug in the Community.

EU Clinical Trials Register. Subjects who have had a previous allergy to PEG-asparaginase but can receive Erwinia are eligible. Both Female Only Male Only. Subjects must have a serum creatinine level that is? How to search [pdf]. Definition of the end of l-asparzginasa trial and justification where it is not the last visit of the last subject undergoing the trial.

Medicinas para Quimioterapia – Nombres de Medicina

Active treatment for graft-versus-host disease 6. Subjects are under 18 years old.


Date on which this record was first entered in the L-aspaaraginasa database:. Trials with results Trials without results. Committee on Advanced therapies CAT has issued a classification for this product.

Subjects must have fully recovered from the acute toxic effects of all previous chemotherapy, immunotherapy, or radiotherapy treatment before enrollment. Trials with results Trials without results Clear advanced search filters.

Clinical Trials Register

Positive culture axversos bacteria or fungus within 14 days of the initiation of therapy 7. Los sujetos deben haber finalizado todo tipo de inmunoterapia activa p. Adequate liver function, defined as both of the following: Review by the Competent Authority or Ethics Committee in the country concerned. Pneumonia AND sponsor name.

l-asparaginasa efectos adversos pdf – PDF Files

Restricciones de tratamientos previos: For these items you should use the filters and not add them to your search terms in the text field. Karnofsky or Lansky scores?

Clear advanced search filters. Clinical trials The European Union Clinical Trials Register allows you to search for protocol and results information on: